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Brand: hby
Customized: Customized
Shelf Life: 2 Years
Purity: ≥50, ≥50%
Origin: China
Certificate: Iso9001
State: Powder
Assay: 99.0~101.0%
Powder: Yes
Certification: Gmp, Hse, Iso 9001, Usp, Bp
Suitable For: Elderly, Adult
Trademark: HBY
Production Capacity: 800000000
Model NO.: HBY-Ai-c-ar
Transport Package: 50mg/Vial, 10vials/Box, or as Customers′ Reque
Specification: 50mg/vial, 10vials/box
Productivity: 80000
Transportation: Ocean,Land,Air,Express
Place of Origin: China
Supply Ability: 80000
Port: shanghai
Payment Type: T/T,Money Gram,Paypal,Western Union
Incoterm: FOB,CFR,CIF,EXW,Express Delivery
Function
Ai-c-ar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that Ai-c-ar blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that Ai-c-ar can mimic the activity of in-su-lin (sc-211647) by activating A-M-P-K (AM-P-activ-at-ed pr-ot-ein k-in-ase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). Ai-c-ar is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
A-M-P-ac-tiv-a-ted pro-te-in kin-a-se (A-M-P-K) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.Ai-c-ar is a selective activator of A-M-P-K in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.Ai-c-ar (0.5 mM) inhibits in-su-lin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
Product Categories : Peptides > Peptides For Bodybuilding
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.
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Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.